Research Progress of Renal Transporters in Polymyxin-induced Nephrotoxicity

VernacularTitle:肾脏转运体在多黏菌素肾毒性中的研究进展
Author: Simin ZHOU ¹ ; Xuemei LUO ; Shuo CHENG ; Weihong GE
Author Information

1. 中国药科大学南京鼓楼医院药学部,南京 210008;中国药科大学基础医学与临床药学学院,南京 210009
Keywords: Polymyxin; Nephrotoxicity; Renal transporters; Megalin
From: Herald of Medicine 2024;43(9):1451-1456
CountryChina
Language:Chinese
Abstract: Polymyxins are the first-line drugs used in multidrug resistance(MDR)Gram-negative infections.Polymyxin-induced nephrotoxicity is the major dose-limiting factor hindering its clinical use.It has been suggested that the mechanism of polymyxin-associated nephrotoxicity is related to its accumulation in the kidney upon extensive reabsorption from renal proximal tubular cells,and one or more renal transporters may mediate the process that polymyxins enter the renal tubular cells across cytomembrane.This review aimed to describe the roles of renal transporters in polymyxins reabsorption into the renal tubular cells and provide reference for reducing the nephrotoxicity of polymyxin.