Research Advances on the Impact of High-altitude Hypoxia on Cardiovascular Drug Metabolism
10.3870/j.issn.1004-0781.2024.06.015
- VernacularTitle:高原低氧影响心血管药物体内代谢的研究进展
- Author:
Mengyue WANG
1
;
Xiangyang LI
Author Information
1. 青海大学药学院,西宁 810100
- Keywords:
High-altitude hypoxia;
Pharmacokinetics;
Drug metabolism enzymes;
Drug Transporter
- From:
Herald of Medicine
2024;43(6):935-940
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic environment at high-altitude significantly affects the cardiovascular system to a certain extent,leading to alterations in drug metabolism in vivo.Pharmacokinetic parameters,expression and function of drug metabolism enzymes and transporters can all be affected.This paper systematically reviews the research progress on the effects of high-altitude hypoxia on the cardiovascular drugs metabolism,discusses changes in pharmacokinetics,drug metabolism enzymes and transporters under high-altitude hypoxia conditions,aiming to provide relevant theoretical support for the study of drug metabolism under high altitude hypoxia conditions.
