Early Predictive Value of Fasting Glucose-to-Lymphocyte Ratio for Persistent Organ Failure in Acute Pancreatitis
10.11969/j.issn.1673-548X.2024.08.011
- VernacularTitle:空腹血糖与淋巴细胞比值对急性胰腺炎持续脏器衰竭的早期预测价值
- Author:
Jie LI
1
;
Xin GAO
;
Yang PAN
Author Information
1. 225000 扬州大学附属医院消化内科/胰腺中心;225000 江苏省扬州市胰腺病重点实验室
- Keywords:
Fasting glucose;
Lymphocyte;
Acute pancreatitis;
Persistent organ failure
- From:
Journal of Medical Research
2024;53(8):53-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the early predictive value of fasting glucose-to-lymphocyte ratio(GLR)in acute pancreati-tis(AP)complicated by persistent organ failure(POF).Methods A total of 677 patients with AP admitted to the Department of Gastro-enterology/Pancreatic Center,Affiliated Hospital of Yangzhou University from January 2015 to December 2020 were collected,of which 602 patients did not have POF(non-POF group)and 77 patients had concurrent POF(POF group).The general data and laboratory in-dicators within 24hours of admission were collected,and Logistic regression analysis was used to explore the risk factors of AP complicated with POF;receiver operating characteristic(ROC)curves were plotted to assess the early prediction efficiency of GLR,neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),computed tomography severity index(CTSI)and Ranson scores in pre-dicting AP complicated with POF.Results GLR,NLR,PLR,CTSI score,and Ranson score were significantly higher in the POF group than those in the non-POF group(P＜0.05),and GLR was an independent risk factor for AP complicated with POF.At an optimal cut-off value of 0.76,the area under the curve(AUC)of GLR for predicting AP complicated with POF was 0.745,with the sensitivity of 75.47％and the specificity of 59.80％.The AUC of GLR predicted AP complicated with POF was better than PLR(z=2.868,P=0.004),and was comparable to NLR and CTSI scores(z=1.304,P=0.183;z=0.538,P=0.588),and the predictive efficacy was worse compared with Ranson score(z=2.973,P=0.001).Conclusion GLR is an independent risk factor for AP complicated with POF and can be used as a better novel hematological indicator for predicting the early occurrence of POF in AP patients.
