Analysis of Early Death in Elderly Patients with Acute Promyelocytic Leukemia Treated with Arsenic Trioxide Induction
10.11969/j.issn.1673-548X.2024.05.010
- VernacularTitle:亚砷酸诱导的老年急性早幼粒细胞白血病早期死亡分析
- Author:
Yu ZHAO
1
;
Tianming HU
;
Bo JIN
Author Information
1. 150001 哈尔滨医科大学附属第一医院实验诊断教研室
- Keywords:
Arsenic trioxide;
Acute promyelocytic leukemia;
Elderly;
Early death;
Risk factors
- From:
Journal of Medical Research
2024;53(5):42-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the occurrence and predictive factors of early death(ED)in elderly(≥60 years old)patients with newly diagnosed acute promyelocytic leukemia(APL)induced by single-agent arsenic trioxide(ATO).Methods The clinical da-ta of 71 consecutive elderly APL patients and 456 consecutive young APL patients were collected.Ten clinical and laboratory parameters,which could be obtained rapidly by clinicians were selected.Chi-square test and Logistic regression analysis were used for statistical a-nalysis.Results The ED rate in elderly patients(22.5％,16/71)was higher than that in young patients(15.1％,69/456),but the difference was not statistically significant(P=0.115).The incidence of infection-related ED(8.5％)and thrombosis-related ED(2.3％)in elderly patients was significantly higher than that in young patients(2.0％and 0.3％,respectively),and the difference was statistically significant(P＜0.01).Peripheral white blood cell count＞10 × 109/L and male were independent risk factors for ED in both the elderly and young patients.And hypoalbuminemia(P＜0.001)and plasma fibrinogen＜1g/L(P=0.001)were still independent risk factors for ED only in young patients.Conclusion When induced by single-agent ATO,the elderly APL patients were significantly different from the young patients in terms of clinical features,incidence and risk factors of ED.Therefore age-stratified study on ED in APL is necessary.
