Prognostic Factors for Distant Metastasis in Patients with Locoregional Recurrence after Mastectomy.
10.4048/jbc.2015.18.3.279
- Author:
Yuri JEONG
1
;
Su Ssan KIM
;
Gyungyub GONG
;
Hee Jin LEE
;
Sei Hyun AHN
;
Byung Ho SON
;
Jong Won LEE
;
Eun Kyung CHOI
;
Sang Wook LEE
;
Seung Do AHN
Author Information
1. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. watermountain@hanmail.net
- Publication Type:Original Article
- Keywords:
Breast neoplasms;
Drug therapy;
Local neoplasm recurrence;
Mastectomy;
Neoplasm metastasis
- MeSH:
Breast Neoplasms;
Diagnosis;
Drug Therapy;
Follow-Up Studies;
Humans;
Lymph Nodes;
Mastectomy*;
Multivariate Analysis;
Neoplasm Metastasis*;
Neoplasm Recurrence, Local;
Radiotherapy;
Recurrence*;
Retrospective Studies;
Thorax
- From:Journal of Breast Cancer
2015;18(3):279-284
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to identify patients with high risk of distant metastasis (DM) after salvage treatment for postmastectomy locoregional recurrence (LRR). METHODS: We retrospectively reviewed 142 patients who received salvage radiotherapy with or without wide excision for isolated LRR after mastectomy between January 1999 and December 2012. Distant metastasis-free survival (DMFS) was estimated from the date of diagnosis of isolated LRR to the date of DM or last follow-up using the Kaplan-Meier method, and Cox regression analysis was performed to identify prognostic factors for DM. RESULTS: The median follow-up period was 54 months. The major failure pattern was DM (56%) and the 5-year DMFS was 43%. In multivariate analysis, initial N (iN) stage, recurrent N (rN) stage, and hormone receptor (HR) status were significant prognostic factors for DM (5-year DMFS: iN0 vs. iN1-3, 73% vs. 25%, p<0.001; rN0 vs. rN1-3, 61% vs. 29%, p<0.001; HR+ vs. HR-, 49% vs. 21%, p<0.001). CONCLUSION: Patients with lymph node involvement and/or HR- specimens seem to experience more DM than patients with chest wall-only recurrence and HR+ specimens. Further studies are needed to investigate the role of chemotherapy in these patients.
