Risk factors for diarrhea in ICU patients with enteral nutrition support: a Meta-analysis
10.3760/cma.j.cn115682-20200805-04748
- VernacularTitle:ICU患者肠内营养支持并发腹泻危险因素的Meta分析
- Author:
Li HE
1
;
Xiangdong HUANG
;
Jingjing MA
;
Yan JIANG
;
Na LI
;
Yanli MAO
;
Yan FEI
;
Xiaoping ZHU
Author Information
1. 同济大学附属第十人民医院重症医学科，上海 200072
- Keywords:
Intensive Care Unit;
Diarrhea;
Enteral nutrition;
Risk factors;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2020;26(35):4861-4868
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors for diarrhea in Intensive Care Unit (ICU) patients with enteral nutrition support by Meta-analysis, so as to provide a basis for the prevention of diarrhea.Methods:Literature on risk factors for diarrhea in ICU patients with enteral nutrition were searched in PubMed, Web of Science, Embase, the Cochrane of Library, China National Knowledge Infrastructure, Wanfang Data and SinoMed by computer from the database building to June 30, 2020. RevMan 5.1 was used for analysis.Results:A total of 14 literatures were included with 16 related risk factors. After Meta-analysis, statistically significant risk factors included hypoproteinemia ( OR=2.51) , age ( OR=2.08) , fasting before enteral nutrition ( OR=4.70) , mechanical ventilation ( OR=2.24) , use time of enteral nutrition preparation ( OR=1.35) , dosage of enteral nutrition preparation ( OR=1.01) , speed of enteral nutrition preparation ( OR=1.03) , potassium tube feeding ( OR=1.65) , antibiotic ( OR=1.98) , gastric motility drugs ( OR=2.06) and acid inhibitor ( OR=2.62) . Conclusions:The risk factors for diarrhea in ICU patients with enteral nutrition support include patient's own and disease factors (hypoproteinemia, age, fasting before enteral nutrition, mechanical ventilation and APACHE Ⅱ) , nutrition preparation factors (use time, dosage and speed of enteral nutrition preparation) as well as drug factors (potassium, antibiotic, gastric motility drugs and acid inhibitor) . Given that there are many risk factors for diarrhea in ICU patients with enteral nutrition support, clinically targeted preventive measures should be taken to reduce the risk of its occurrence.
