Oral lichenoid drug reactions induced by secukinumab injection:a case report
10.12173/j.issn.1005-0698.202311027
- VernacularTitle:司库奇尤单抗注射液致口腔苔藓样药物反应1例
- Author:
Dandan LI
1
;
Zixin WAN
;
Jianli WANG
Author Information
1. 口腔疾病防治全国重点实验室/国家口腔医学中心/国家口腔疾病临床医学研究中心/四川大学华西口腔医院药剂科(成都 610041)
- Keywords:
Secukinumab;
Oral lichenoid drug reactions;
Adverse drug reactions
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(4):461-465
- CountryChina
- Language:Chinese
-
Abstract:
A 57-year-old female patient was treated with secukinumab injection for psoriasis.After the eighth administration,large area of reticular streaks with hyperemia and erosion appeared on the dorsum of the tongue and left buccal mucosa,which improved after three weeks of corticosteroids treatment.The symptoms worsened after re-administration and a diagnosis of an oral lichenoid drug reaction(OLDR)was made,which improved after eight weeks of corticosteroids treatment.There was no recurrence four months after secukinumab injection withdrawal.By correlation analysis,the causal relationship between OLDR and Secukinumab injection was evaluated as"be sure",which had not been reported in China.The clinical manifestations of oral lichenoid drug reactions were unilateral buccal mucosa with hyperemia and erosion.Discontinuation of suspected drugs and topical application of corticosteroids were the most effective treatments.
