Effect of lateral decubitus hand position pad on tumor micrometastasis and trauma response in patients with non-small cell lung cancer
10.3760/cma.j.cn115455-20230621-00683
- VernacularTitle:非小细胞肺癌术应用侧卧位手部体位垫对患者肿瘤微转移、创伤反应的影响
- Author:
Na LI
1
;
Xiaodi LIU
Author Information
1. 浙江金华广福肿瘤医院胸部肿瘤外科，金华 321000
- Keywords:
Carcinoma, non-small-cell lung;
Neoplasm micrometastasis;
Lateral decumbent position;
Hand position pad;
Stress disorders, traumatic
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(10):912-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of lateral decubitus hand position pad on tumor micrometastasis and trauma response in patients with non-small cell lung cancer.Methods:Seventy-eight patients with non-small cell lung cancer (45 patients in stage Ⅰ, and 33 cases in stage Ⅱ) admitted to Zhejiang Jinhua Guangfu Cancer Hospital from January 2020 to January 2022 and performed single-aperture thoracoscopic radical resection of non-small cell lung cancer was retrospectively selected, and they were divided into control group (38 cases, adopted traditional body positioning) and study group (40 cases, adopted lateral decubitus hand position pad). Postural indicators, expression levels of metastatic genes, tumor markers, pain degree and stress response indicators were compared between the two groups.Results:The success rate of one position placement in the study group was higher than that in the control group: 100.00%(40/40) vs. 78.95%(30/38); the incidence of surgical skin compression and limb discomfort were lower than those in the control group: 2.50%(1/40) vs. 26.32%(10/38), 5.00%(2/40) vs. 28.95%(11/38); the position placement time was short than that in the control group: (8.47 ± 1.38) min vs.(12.42 ± 2.03) min, there were statistical differences ( P<0.05). Three months after surgery, the expressions of tumor necrosis factor receptor-associated protein 1(TRAP1), matrix metalloproteinase-9 (MMP-9) in the study group were lower than those in the control group: 0.56 ± 0.07 vs. 0.85 ± 0.10, 0.32 ± 0.04 vs. 0.54 ± 0.06, the expressions of E-cadherin and Kruppel-like factor 4(KLF4) in the study group were higher than those in the control group: 1.69 ± 0.22 vs. 1.36 ± 0.17, 2.25 ± 0.37 vs. 1.98 ± 0.20, there were statistical differences ( P<0.05). Three months after surgery, the levels of carcinoembryonic antigen (CEA), cytokeratin (CYFRA21-1) in the study group were lower than those in the control group: (36.89 ± 4.12) μg/L vs. (41.72 ± 5.34) μg/L, (7.25 ± 0.81) μg/L vs. (8.01 ± 1.34) μg/L, there were statistical differences ( P<0.05). At 1-day after surgery, the levels of prostaglandin E2 (PGE2), cortisol (Cor) and substance P (SP) in the study group were lower than those in the control group: (110.47 ± 10.12) pg/L vs. (138.88 ± 14.42) pg/L, (60.37 ± 7.18) ng/L vs. (71.34 ± 8.01) ng/L, (6.26 ± 0.81) μg/L vs. (8.25 ± 1.17) μg/L, there were statistical differences ( P<0.05). Conclusions:The application of lateral decubitus hand position pad in single-aperture thoracoscopic radical resection of non-small cell lung cancer can improve the patient′s position and improve the surgical effect, thus reducing the trauma reaction and effectively inhibiting tumor micrometastasis.
