Serum levels of lipoxin A4 and cysteine-rich protein 61 in patients with knee osteoarthritis and their correlation with disease severity
10.3760/cma.j.cn115455-20230620-00673
- VernacularTitle:膝骨关节炎患者血清脂氧素A4、富含半胱氨酸蛋白61水平及其与病情严重程度的相关性
- Author:
Huan HAO
1
;
Jianguang ZHU
;
Xue RONG
Author Information
1. 咸宁市中心医院（湖北科技学院附属第一医院）检验科，咸宁 437100
- Keywords:
Osteoarthritis, knee;
Lipoxin-A4;
Cysteine-rich protein 61;
Severity of illness
- From:
Chinese Journal of Postgraduates of Medicine
2024;47(6):522-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between the levels of serum lipoxin A4 (LXA4), cysteine-rich protein 61 (Cyr61) and disease severity in patients with knee osteoarthritis.Methods:A total of 106 patients with knee osteoarthritis treated in the Xianning Central Hospital (the First Affiliated Hospital of Hubei University of Science and Technology) from October 2017 to October 2019 were selected as the study subjects, and the patients were divided into mild to moderate group (63 cases) and severe group (43 cases) according to the Kellgren-Lawrence (K-L) grading criteria. Meanwhile 80 healthy subjects who underwent physical examination during the same period were selected as the control group. The levels of serum LXA4 and Cyr61 were detected by enzyme-linked immunosorbent assay. Spearman correlation was used to analyze the correlation between serum LXA4 and Cyr61 levels and the severity of knee osteoarthritis. Logistic regression was used to analyze the influencing factors of the severity of knee osteoarthritis. Receiver operative characteristic (ROC) curve was used to analyze the predictive efficacy of serum LXA4 and Cyr61 in patients with severe knee osteoarthritis.Results:The serum LXA4 level in the control group was (56.47 ± 9.62) μg/L , which was significantly higher than that in the mild to moderate group (46.16 ± 7.77) μg/L and the severe group (39.57 ± 6.20) μg/L, and the serum LXA4 level in the mild to moderate group was higher than that in the severe group, there were statistical differences ( P<0.05). The serum Cyr61 level in the control group was (25.07 ± 2.77) ng/L, which was significantly lower than that in the mild to moderate group (89.76 ± 10.47) ng/L and the severe group (96.88 ± 8.47) ng/L, and the serum LXA4 level in the mild to moderate group was lower than that in the severe group, there were statistical differences ( P<0.05). Spearman correlation analysis showed that the severity of disease in patients with knee osteoarthritis was negatively correlated with serum LXA4 level ( r = - 0.451, P<0.05) and positively correlated with serum Cyr61 level ( r = 0.358, P<0.05). The results of Logistic regression analysis showed that serum Cyr61 and LXA4 were predictors of the severity of knee osteoarthritis ( P<0.05). The area under the curve (AUC) of combination of serum LXA4 and Cyr61 in predicting severe knee osteoarthritis was 0.819, the sensitivity was 79.07%, and the specificity was 79.34%. Conclusions:The decrease of serum LXA4 level and the increase of Cyr61 level in patients with knee osteoarthritis are related to the severity of the disease. The combination of the two has the ability of clinical auxiliary diagnosis of the severity of osteoarthritis.
