Value of two-dimensional shear wave elastography in diagnosis of liver fibrosis in patients with type 2 diabetes mellitus and non-alcoholic fatty liver
10.19745/j.1003-8868.2024177
- VernacularTitle:二维剪切波弹性成像对2型糖尿病合并非酒精性脂肪肝病患者肝纤维化的诊断价值
- Author:
Chun-Ying LIU
1
;
Qing XU
;
Fei WANG
;
Lei GAO
Author Information
1. 天津医科大学朱宪彝纪念医院,天津市内分泌研究所,天津市代谢性疾病重点实验室,国家卫生健康委激素与发育重点实验室,天津 300134
- Keywords:
two-dimensional shear wave elastography;
type 2 diabetes mellitus;
non-alcoholic fatty liver disease;
liver stiff-ness measurement;
progressive hepatic fibrosis
- From:
Chinese Medical Equipment Journal
2024;45(9):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of two-dimensional shear wave elastography(2D-SWE)in the diagnosis of liver fibrosis in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 100 patients with T2DM complicated with NAFLD from some hospital were selected and was divided into three groups based on the degree of NAFLD including a mild group(38 cases),a moderate group(35 cases)and a severe group(27 cases).The values of liver stiffness measurement(LSM)in different degrees of fatty liver of the three groups were compared;the receiver operating characteristic(ROC)curve was used to evaluate the efficacy of 2D-SWE technique in diagnosing progressive liver fibrosis in T2DM patients with NAFLD.SPSS 26.0 statistical software was used for data analysis.Results The three groups had significant differences in LSM value(P＜0.001),and the differences of the LSM values between the mild and moderate groups and between the mild and severe groups were all statistically significant(P＜0.001),while the moderate and severe groups had no obvious difference in LSM value(P=0.065),with the LSM value increasing with the aggravation of NAFLD.There were 16 patients with progressive hepatic fibrosis and 84 ones with non-progressive hepatic fibrosis,and the median LSM value of patients with progressive heaptic fibrosis(8.3 kPa)significantly higher than that of patients with non-progressive hepatic fibrosis(5.0 kPa)(P＜0.001).The ROC curve showed that the area under the curve(AUC)of 2D-SWE for the diagnosis of progressive liver fibrosis in T2DM patients with moderate and severe fatty liver was 0.896[95％confidence interval(CI):0.819-0.974],and the diagnostic sensitivity and the specificity was 92.3％and 83.7％respectively when the optimal cut-off value was 7.85 kPa.Conclusion The quantitative results of the LSM values measured by 2D-SWE technology differ in patients with different degrees of NAFLD,which can be used for auxiliary diagnosis of the degree of NAFLD and behaves well in diagnosing progressive hepatic fibrosis of patients with type 2 diabetes mellitus complicated with NAFLD.[Chinese Medical Equipment Journal,2024,45(9):73-77]
