Effect of transcranial direct current stimulation on upper limb motor function in chronic-phase stroke patients with hemiplegia
10.19745/j.1003-8868.2024032
- VernacularTitle:经颅直流电刺激对慢性期脑卒中偏瘫患者上肢运动功能的疗效分析
- Author:
Xin-Xin CHENG
1
;
Ling-Ling ZHANG
;
Wan LIU
;
Li LIU
;
Yong-Chao YANG
;
Run GAO
;
Hui-Min ZHU
;
Chuan-Wen ZHANG
Author Information
1. 南京医科大学附属脑科医院康复医学科,南京 210029
- Keywords:
dual-hemispheric transcranial direct current stimulation;
chronic-phase stroke;
upper limb motor dysfunction;
functional connectivity;
hemiplegia
- From:
Chinese Medical Equipment Journal
2024;45(2):67-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of dual-hemispheric transcranial direct current stimulation(Dual-tDCS)on upper limb motor function in chronic-phase stroke patients to provide theoretical references for neural mechanisms-based treatment of upper limb dysfunction.Methods Totally 24 chronic-phase stroke patients with upper limb motor dysfunction were selected from some hospital and divided into an experimental group(n=13)and a control group(n=11)the random number table.The control group was treated with tDCS pseudo-stimulation combined with conventional rehabilitation,while the experimental group was given with Dual-tDCS combined with conventional rehabilitation.The patient activities were assessed before and after treatment with Fugl-Meyer assessment upper limb scale(FMA-UL)and activities of daily living(ADL)scale.The changes of primary motor cortex(M1 area)and whole brain functional connectivity(FC)were compared before and after treatment.SPSS 24.0 statistical software was used for data analysis.Results After treatment,the two groups both had the FAM-UL and ADL scores increased significantly,and the experimental group had the scores statistically higher than those of the control group,and the differences were all statistically significant(P＜0.05).In the control group,the analysis on M1 area and whole brain FC after treatment indicated the FC decreased from M1 area at the unaffected side to midoccipital gyrus at the affected side and lingual gyrus and healthy angular gyrus at the unaffected side;there were no brain areas with changed FC found(P＜0.01).In the experimental group,the FC was lowered from M1 area at the unaffected side to cerebellum and cerebellar vermis at the unaffected side,while raised to precentral gyrus at the affected side(P＜0.01);the FC ascended from M1 area at the affected side to cerebellum and middle temporal gyrus at the affected side,while declined to precentral gyrus at the unaffected side(P＜0.01).Conclusion The neuromodulatory effect of Dual-tDCS on the brain improves FC in motor and non-motor-related brain areas in chronic-phase stroke patients,and may contribute to rehabilitation of upper limb motor dysfunction in chronic-phase stroke.[Chinese Medical Equipment Journal,2024,45(2):67-73]
