Application of 3D-T1WI surface-based morphometry in assessment of brain structure in preschool children with non-lesional epilepsy
10.19745/j.1003-8868.2024031
- VernacularTitle:3D-T1WI表面形态学分析在学龄前无灶性癫痫患儿脑结构评估中的应用
- Author:
Jian-Qiu JIANG
1
;
Nan ZHANG
;
Peng ZHANG
;
Chuan-Zhen BIAN
Author Information
1. 南京医科大学附属儿童医院放射科,南京 210008
- Keywords:
3D-T1WI;
surface-based morphometry;
non-lesional epilepsy;
brain structure
- From:
Chinese Medical Equipment Journal
2024;45(2):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of brain structure in preschool children with non-lesional epilepsy(NLE)by analyzing their 3D-T1WI brain structural images with surface-based morphometry(SBM).Methods Thirty-five preschool children with diagnosed NLE in the neurology department of some hospital from January 2021 to September 2022 were enrolled into a NLE group,and 35 healthy preschool children from the same period were included in a control group.The two groups were compared in terms of cortical thickness,sulcus depth,gyrus index,cerebrospinal fluid volume,gray matter volume and white matter volume.SPSS 25.0 software was used for statistical analysis.Results When compared with the control group,the NLE group had the thicknesses of temporal lobe cortex decreased at both left and right sides while the thickness of cingulate cortex increased on the right,and the differences were statistically significant(P＜0.05);the NLE group had the depths of sulcus in lingual gyrus and middle frontal gyrus of right cerebral hemisphere reduced,and the differences were statistically significant(P＜0.05);the NLE group had the gyrus index of left cerebral hemisphere talus cortex highered,and the differences were statistically significant(P＜0.05).There were no significant differences between the two groups in cerebrospinal fluid,gray matter and white matter(P＞0.05).Conclusion Cortical structural abnormalities in children with NLE may be a major factor in its pathogenesis.SBM can be used to evaluate localized brain structural abnormalities in NLE children by analyzing their 3D-T1WI brain structural images,and thus can be an effective tool for determining the potential pathogenesis of NLE in children.[Chinese Medical Equipment Journal,2024,45(2):62-66]
