Focusing on innovative drug therapy for neovascular age-related macular degeneration

VernacularTitle:关注新生血管性年龄相关性黄斑变性的创新药物治疗
Author: Yingyi LU ¹ ; Jing ZHAO ; Hong DAI
Author Information

1. 北京医院眼科　国家老年医学中心　中国医学科学院老年医学研究院，北京　100730
Keywords: Age-related macular degeneration; Treatment; Anti-VEGF; Innovative drug
From: Chinese Journal of Experimental Ophthalmology 2024;42(5):401-407
CountryChina
Language:Chinese
Abstract: Wet age-related macular degeneration (nAMD) is the leading cause of blindness in the elderly, and anti-VEGF is its main treatment method.At present, the treatment of nAMD still faces many shortcomings and challenges, and the development of new therapeutic drugs and delivery methods is the research focus.In recent years, the direction of drug research and development for the treatment of nAMD has shown diversification, including the development of new target/mechanism drugs and new drug delivery methods, optimization of drug dosage and gene therapy, etc., in order to reduce treatment frequency, prolong treatment interval, improve patient compliance, and maintain or improve vision in the long term.Ophthalmologists should have a comprehensive understanding of new drugs and explore strategies appropriate for patients with different subtypes of nAMD to achieve a move toward precision medicine.