Recent advances in pathogenesis and treatment of optic nerve injury in glau-coma
10.13389/j.cnki.rao.2024.0110
- VernacularTitle:青光眼视神经损伤的发病机制及治疗研究最新进展
- Author:
Xuemei WANG
1
;
Chao QU
Author Information
1. 646000 四川省泸州市,西南医科大学附属医院眼科
- Keywords:
glaucoma;
retinal ganglion cells;
ferroptosis;
autophagy
- From:
Recent Advances in Ophthalmology
2024;44(7):572-577
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is a blinding eye disease characterized by progressive visual field defects.It poses a significant challenge worldwide because of the irreversible and non-selective death of retinal ganglion cells(RGCs)it causes,resulting in impaired visual function.The traditional belief is that pathological elevation of intraocular pressure(IOP)is the primary mechanism of optic nerve injury.However,this explanation doesnt account for the damage to RGCs and the optic nerve in glaucoma patients with normal IOP.Additionally,controlling IOP cannot reverse preexisting visual dysfunction.In recent years,extensive research has delved into the pathogenesis of damage to RGCs and the optic nerve in glaucoma patients,fo-cusing on non-apoptotic RGCs death,local activation of glial cells,neurotransmitter toxicity,and mitochondrial dysfunc-tion.Based on these,numerous protective interventions for RGCs have been proposed.This article summarizes the latest progress of research on the mechanism of glaucomatous optic nerve injury and related treatments,providing a theoretical basis for further research on how to prevent and treat glaucomatous optic nerve injury.
