Advances in the role of platelet-derived growth factor in neovascularisation and fibrosis in neovascular age-related macular degeneration
10.13389/j.cnki.rao.2024.0080
- VernacularTitle:血小板源性生长因子在湿性年龄相关性黄斑变性新生血管及纤维化中的作用研究进展
- Author:
Tiantian ZHANG
1
;
Jing LI
;
Zhen TIAN
Author Information
1. 710021 陕西省西安市,西安医学院;710068 陕西省西安市,陕西省人民医院眼科
- Keywords:
platelet-derived growth factor;
age-related macular degeneration;
macular choroidal neovascularization;
fibrosis;
pathogenesis
- From:
Recent Advances in Ophthalmology
2024;44(5):410-414
- CountryChina
- Language:Chinese
-
Abstract:
Macular choroidal neovascularization(MNV)and subretinal fibrosis(SRFi)are the most common patho-mechanisms of neovascular age-related macular degeneration(nAMD),which often lead to irreversible vision loss in people over 50 years of age.Even though there is an effective clinical medication known as anti-vascular endothelial growth factor(VEGF),nearly 50％of patients lose vision due to scars produced by SRFi.Platelet-derived growth factors(PDGF)are pro-angiogenic factors isolated from human platelets.It has been known that they play a role in choroidal neovasculariza-tion in the macula,but the specific mechanism of action remains unclear.This article reviews the mechanism of PDGF in neovascularization and SRFi formation in nAMD,providing data for the future development of new diagnostic and therapeu-tic methods.
