Correlation and significance of the C-reactive protein to albumin ratio,angiopoietin-2 and receptor for advanced glycation end product with the outcomes of patients infected with carbapenem-resistant Enterobacteriaceae
10.7683/xxyxyxb.2024.11.015
- VernacularTitle:C反应蛋白与白蛋白比值、血管生成素-2、晚期糖基化终末产物受体与碳青霉烯耐药肠杆菌科细菌感染患者病情转归的相关性及意义
- Author:
Ni CHEN
1
;
Cuiying ZHAO
Author Information
1. 陕西省森林工业职工医院检验科,陕西 西安 710300
- Keywords:
C-reactive protein to albumin ratio;
angiopoietin-2;
receptor for advanced glycation end product;
carbapenem-resistant Enterobacteriaceae;
bacterial infection;
outcome
- From:
Journal of Xinxiang Medical College
2024;41(11):1080-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation and significance of the C-reactive protein/albumin ratio(CRP/ALB),angiopoietin-2(Ang-2),and receptor for advanced glycation end product(RAGE)with the outcomes of patients infected with carbapenem-resistant Enterobacteriaceae(CRE).Methods A total of 103 patients with severe and long-term repeated CRE infections who were admitted to the Sengong Hospital of Shaanxi Province from January 2020 to May 2023 were selected as the research subjects.The patients were divided into poor outcome group(n=23)and good outcome group(n=80)according to the different outcomes within 28 days.The clinical data of patients were collected by reviewing the electronic medical record system,including age,gender,body mass index,medical history,bacterial species,body temperature,whether invasive mechanical ventilation was performed,and whether complicated infectious shock.The serum CRP level was detected with a fully automated electrochemiluminescence immunoassay analyzer,the ALB level was detected with a fully automated biochemical analyzer,and the CRP/ALB was calculated;the levels of serum Ang-2 and RAGE were detected using a multi-function microplate reader.Clinical data and levels of CRP/ALB,Ang-2,and RAGE before treatment,3 days and 7 days after treatment were compared between the two groups.The influencing factors associated with the outcomes of patients with CRE infection were analyzed using Cox regression.The predictive value of CRP/ALB,Ang-2 and RAGE levels before treatment for outcomes of patients with CRE infection was analyzed using the receiver operating characteristic curve.The prognosis at 28 days of patients with different levels of CRP/ALB,Ang-2,and RAGE was analyzed using the Kaplan-Meier curve.Results The proportions of patients with invasive mechanical ventilation and infectious shock in the poor outcome group were significantly higher than those in the good outcome group(P＜0.05).The CRP/ALB,Ang-2,and RAGE levels were significantly lower after 3 and 7 days of treatment than those before treatment and were significantly lower after 7 days of treatment than those after 3 days of treatment in the good outcome group(P＜0.05).There was no significant difference in CRP/ALB,Ang-2,and RAGE levels at different time points in the poor outcome group(P＞0.05).The C RP/ALB,Ang-2,and RAGE levels in the poor outcome group were significantly higher than those in the good outcome group after 3 and 7 days of treatment(P＜0.05).Invasive mechanical ventilation,complicated with infectious shock,and increased CRP/ALB,Ang-2 and RAGE levels were independent risk factors for the outcome of CRE infection(P＜0.05).After 7 days of treatment,CRP/ALB+Ang-2+RAGE had the highest area under the curve(0.931)for predicting the outcome of CRE infection,with a sensitivity of 86.96％and a specificity of 88.75％.The survival rates of patients in the high-expression subgroups of C RP/ALB,Ang-2,and RAGE were significantly lower than those in the low-expression subgroups(P＜0.05).Conclusion CRP/ALB,Ang-2 and RAGE are related to the outcome of CRE infection.Combined detection can be used as an early prediction scheme for the outcome of CRE infection,providing accurate and quantified guidance information for clinical stratified management.
