Effect of safflower yellow pigment injection combined with alprostadil on patients after coronary artery bypass grafting
10.3969/j.issn.1008-0074.2024.05.16
- VernacularTitle:红花黄色素注射液联合前列地尔治疗对冠状动脉旁路移植术后患者的影响
- Author:
Xin-Hua ZHANG
1
;
Chun-Mei REN
;
Li-Jie JIANG
;
Wei-Guang YANG
;
Hong-Ling SU
;
Jing-Yu ZHAO
Author Information
1. 邯郸市中心医院心血管外科,河北邯郸 056002
- Keywords:
Coronary disease;
Coronary artery bypass,off-pump;
Alprostadil
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(5):590-593
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of safflower yellow pigment injection combined with alprostadil on patients after coronary artery bypass grafting(CABG).Methods:A total of 92 patients with coronary heart disease who received CABG in Department of Cardiovascular Surgery,Handan Central Hospital between September 2018 and September 2020 were selected.According to order of admission,they were divided into control group(n=46,from September 2018 to Sep-tember 2019,routine therapy+alprostadil after CABG)and study group(n=46,from October 2019 to September 2020,safflower yellow pigment injection based on control group),both groups were treated for 28d.On 3d after drug withdraw-al,therapeutic effect,cardiac function indexes,four myocardial enzyme spectrum and perioperative indexes were compared between two groups.Results:On 3d after drug withdrawal,compared with control group,patients in study group had sig-nificant higher total effective rate(73.9％vs.91.3％),left ventricular ejection fraction(LVEF)[(55.77±4.48)％vs.(62.18±4.21)％](P=0.028,＜0.001),and significant lower left atrial diameter(LAD)[(36.83±3.45)mm vs.(32.09±3.23)mm],left ventricular end-diastolic diameter(LVEDd)[(49.04±4.65)mm vs.(43.83±5.24)mm],levels of creatine kinase(CK)[(125.13±14.21)U/L vs.(62.56±8.42)U/L],lactate dehydrogenase(LDH)[(203.58±31.63)U/L vs.(156.07±22.26)U/L],aspartate aminotransferase(AST)[(44.25±12.98)U/L vs.(35.41±12.37)U/L]and creatine kinase isoenzyme MB(CK-MB)[(28.11±9.84)U/L vs.(17.59±7.41)U/L](P＜0.001 all).Conclusion:The combination of safflower yellow pigment injection and alprostadil can improve the thera-peutic effect and heart function,and reduce myocardial injury in patients after CABG.
