Therapeutic effect of aspirin combined with ticagrelor on unstable angina pectoris and its effect on ser-um IL-6,Bip and CHOP levels
10.3969/j.issn.1008-0074.2024.05.15
- VernacularTitle:阿司匹林联合替格瑞洛对不稳定型心绞痛的疗效及血清IL-6、Bip和CHOP水平的影响
- Author:
Xin JIN
1
;
Cheng-Yue TANG
;
An-Fang CHEN
Author Information
1. 成都市双流区第一人民医院心血管内科,四川成都 610000
- Keywords:
Angina,unstable;
Aspirin;
Ticagrelor;
Inflammation;
Endoplasmic reticulum stress
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(5):585-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study therapeutic effect of aspirin combined with ticagrelor on unstable angina pectoris(UAP)and its effect on serum levels of interleukin-6(IL-6),binding immunoglobin protein(Bip)and C/EBP homologous protein(CHOP).Methods:A total of 120 UAP patients who were treated in Chengdu Shuangliu Dis-trict First People's Hospital between January 2021 and December 2021 were selected.According to random number table,they were equally divided into combined treatment group(aspirin combined ticagrelor therapy)and aspirin group(aspirin therapy).After 90d treatment,total effective rate,cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF),frequency and duration of angina,serum levels of IL-6,Bip and CHOP be-fore and after treatment were compared between two groups,as well as incidence of adverse reaction.Results:The total effective rate in combined treatment group was significantly higher than that of aspirin group(95.00％vs.81.67％,P=0.023).Compared with patients in aspirin group after treatment,patients in combined treatment group had significant higher CO[(4.79±0.95)L/min vs.(5.27±1.05)L/min],SV[(52.32±5.25)ml vs.(56.53±4.78)ml]and LVEF[(48.73±4.41)％vs.(54.89±4.77)％],and significant lower frequency[(3.27±0.75)times/week vs.(2.23±0.73)times/week]and duration of angina[(5.42±0.79)min/time vs.(3.51±0.66)min/time],and serum levels of IL-6[(13.49±1.41)pg/L vs.(6.70±0.84)pg/L],Bip[(24.50±1.41)μg/Lvs.(7.45±0.58)μg/L]and CHOP[(35.56±2.69)μg/L vs.(16.66±2.55)μg/L](P＜0.05 or＜0.01).There was no significant difference in incidence of adverse reactions between two groups(P=0.752).Con-clusion:Aspirin combined with ticagrelor possesses obvious curative effect in treatment of patients with unstable an-gina pectoris.It can significantly improve cardiac function,reduce the inflammatory response and endoplasmic re-ticulum stress in these patients.
