Expressions of serum lncRNA MIAT and miR-150-5p in patients with coronary heart disease and their correlation with coronary artery plaque
10.3969/j.issn.1008-0074.2024.05.08
- VernacularTitle:冠心病患者血清lncRNA MIAT和miR-150-5p表达及其与冠状动脉斑块的相关性
- Author:
Fei-Chuang JING
1
;
Li-Yuan SHI
;
Jing SUN
Author Information
1. 河北中石油中心医院心内科,河北廊坊 065000
- Keywords:
Coronary disease;
Plaque,atherosclerotic;
RNA,Untranslated;
MicroRNAs
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(5):549-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate association of expression levels of serum long non-coding RNA(lncRNA)myo-cardial infarction-associated transcript(lncRNA MIAT)and microRNA-150-5p(miR-150-5p)with coronary artery plaque in patients with coronary heart disease(CHD).Methods:A total of 260 CHD patients admitted in Hebei Petro China Central Hospital between October 2016 and January 2022 were selected.According to coronary angiography(CAG)results,they were divided into stable angina pectoris(SAP)group(n=97)and acute coronary syndrome(ACS)group(n=163),another 97 patients who were excluded for CHD by CAG simultaneously were re-garded as control group.Expression levels of serum lncRNA MIAT and miR-150-5p were measured in all groups;CHD patients received intravascular ultrasound(IVUS)examination,and coronary artery plaque related indexes were compared between SAP group and UAP group.Pearson method was used to analyze the association of expres-sion levels of serum lncRNA MIAT and miR-150-5p with coronary artery plaque related indexes in ACS patients.Results:Compared with control group,SAP group and ACS group had significant higher serum lncRNA MIAT ex-pression level,and significant lower miR-150-5p expression level(P＜0.001 all);compared with SAP group,ACS group had significant higher lncRNA MIAT expression level,vascular remodeling index,necrosis core(NC)area,plaque eccentricity index,and significant lower miR-150-5p expression level and fibrous fat fraction(FF)area(P＜0.001 all).Pearson correlation analysis indicated that in ACS patients,serum lncRNA MIAT expression level was positively correlated with vascular remodeling index,NC area and plaque eccentricity index(r=0.537,0.484,0.392,P＜0.001 all),and inversely correlated with FF area(r=-0.496,P＜0.001);miR-150-5p ex-pression level was inversely correlated with vascular remodeling index,NC area and plaque eccentricity index(r=-0.403,-0.584,-0.546,P＜0.001 all),and positively correlated with FF area(r=0.388,P＜0.001).Conclu-sion:The expression levels of serum lncRNA MIAT and miR-150-5p are abnormal in CHD patients.Expression levels of serum lncRNA MIAT and miR-150-5p are related to coronary artery plaques in ACS patients,which has important significance for clinical diagnosis,prevention and treatment.
