Association between the polymorphism of chromosome 9p21 and the susceptibility of acute non-cardio-genic cerebral infarction in Xinjiang Uygur patients and clinical related characteristic analysis
10.3969/j.issn.1008-0074.2024.04.01
- VernacularTitle:染色体9p21多态性与新疆维吾尔族急性非心源性脑梗死易感性的关系及临床相关特征分析
- Author:
Yiming·Waisiding MAIMAI-TI
1
;
Yiming KSAERJIANG·MAIMAITI
;
Cilina·Tuohan GU
;
Keyoumu·Yasheng Budu A
;
Hai-Yan JIN
;
Yinuer·Abudusaimaiti A
;
Hong-Mei LI
;
Xidamu·Maimaiti RE
Author Information
1. 新疆维吾尔自治区喀什地区第二人民医院神经内科,新疆喀什 844000
- Keywords:
Brain infarction;
Carotid artery diseases;
Polymorphism,single nucleotide
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):381-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the relationship between the distribution of chromosome 9p21 region rs10757274,rs7044859,rs4977574 and rs496892 gene polymorphisms and susceptibility to cerebral infarction in Uyghur patients with acute non-cardiogenic cerebral infarction(ANCCI)in Xinjiang.Methods:A total of 178 Uyghur ANCCI pa-tients who admitted to Second People's Hospital of Kashgar Prefecture of Xinjiang Uygur Autonomous Region from Jan 2012 to Dec 2015 were selected,including 117 cases with and 61 cases without carotid plaque.Gene polymor-phism analysis and comparison of rs10757274,rs7044859,rs4977574,rs496892 loci in chromosome 9p21 region of two groups was performed by applying polymerase chain reaction-high temperature ligase detection reaction(PCR-LDR)technique.Results:Compared with no carotid plaque group,there was significant rise in G allele frequen-cy of rs4977574(44.3％vs.53.0％),and significant reduction in AA genotype frequency of rs4977574(37.7％vs.20.5％)in carotid plaque group(P＜0.05 both).The risk of carotid plaque in patients carrying GG genotype and AG genotype of rs4977574 was 2.476 and 2.285 times of that of those with AA genotype.Compared with non-GG genotype group,there were significant rise in proportions of diabetes(16.3％vs.30.2％),small vessel disease(42.2％vs.60.5％)and systolic blood pressure[(135.91±20.89)mmHg vs.(143.57±20.34)mmHg]in GG genotype group(P＜0.05 all).Conclusion:The rs4977574 gene polymorphism in chromosome 9p21 is associated with susceptibility to developing carotid plaque in Uyghur patients with acute non-cardiogenic cerebral infarction,and GG-pure mutations at this locus may predict an increased risk of small vessel disease.
