Prognostic value and imaging features of 18F-FDG PET-CT in follicular lymphoma with different histopathology grade
10.3760/cma.j.cn121090-20240208-00059
- VernacularTitle:不同病理组织学分级滤泡淋巴瘤的临床PET-CT影像特征及预后研究
- Author:
Tong ZHAO
1
;
Min BAI
;
Rui WANG
;
Ming ZHAO
;
Rongrong TIAN
;
Jun XING
;
Yanmei LIN
;
Jie ZHOU
;
Ling YUAN
Author Information
1. 山西省肿瘤医院、中国医学科学院肿瘤医院山西医院、山西医科大学附属肿瘤医院核医学PET/CT中心，太原 030013
- From:
Chinese Journal of Hematology
2024;45(8):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Follicular lymphoma (FL) is highly heterogeneous with different histopathologic grades. Its biological characteristics and clinical management are different. This study retrospectively analyzed 18F-FDG PET-CT metabolic parameters, clinical features, and their relationship with prognosis in 161 FL patients with different histopathological grades (grade 1-2, grade 3A, grade 3B) at the Shanxi Cancer Hospital. There were 93 cases in the grade 1-2 group, 40 cases in the grade 3A group, and 28 cases in the grade 3B group. The expression of LDH, CD10, EZH2, c-Myc, and CD37 proteins was correlated with histological grade (grade 1-2, grade 3A, and grade 3B) (all P values<0.05) . The SUVmax, TLG, TBR, and TLR for the three groups were different (all P values<0.05) . The optimal thresholds of SUVmax, MTV, TLG, TBR, and TLR for predicting FL disease progression were 8.32, 201.31, 2 342.55, 6.56, and 3.52, respectively, and the rate of disease progression increased in patients with higher thresholds (all P value<0.05) . β 2-MG (>2.3 μg/L) , Follicular lymphoma international prognostic index-1 (FLIPI-1) score (3-5 points) , negative CD37 expression, positive c-Myc expression, and TLG (>2 342.55 g) were all independent risk factors for PFS in the FL patients ( HR=3.609, 2.509, 0.255, 3.506, 13.531, all P value<0.05) . 18F-FDG PET-CT is a powerful complement to FL histopathological grading and the combination of the two may better predict the prognosis of FL patients.
