Clinical analysis on the impact of pretransplant iron overload on allogeneic hematopoietic stem cell transplantation for patients with acquired severe aplastic anemia in pediatric

VernacularTitle:重型再生障碍性贫血儿童接受异基因造血干细胞移植前铁过载对疗效影响的临床研究
Author: Li YAN ¹ ; Hao XIONG ; Fei LONG ; Zhi CHEN ; Zhuo WANG ; Li YANG ; Fang TAO ; Yan CHEN ; Na SONG ; Ming WU
Author Information

1. 华中科技大学同济医学院附属武汉儿童医院儿童血液疾病研究室，武汉　430016
From: Chinese Journal of Hematology 2024;45(6):586-590
CountryChina
Language:Chinese
Abstract: This study aimed to investigate the effect of iron overload on the transplant outcomes of pediatric patients with severe aplastic anemia (SAA) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). A retrospective analysis was conducted on the clinical data of 74 children with SAA who received allo-HSCT at the Hematology Department of Wuhan Children’s Hospital between January 2018 and August 2022. Children with iron overload (serum ferritin >1 000 μg/L) before transplantation had a longer disease course, received more red blood cell transfusions, and had a higher number of CD34 + cells infused. Moreover, iron overload significantly delayed the reconstitution of regulatory T cells after transplantation, increasing the incidence of hemorrhagic cystitis and grade Ⅲ-Ⅳ acute graft-versus-host disease after transplantation. However, iron overload did not significantly affect the overall survival and failure-free survival rates of the children.