Clinical Characteristics of Six Patients with Persistent Real Low-level Elevation of Human Chorionic Gonadotropin
10.3969/j.issn.1674-9081.2015.03.010
- VernacularTitle:持续性真性低水平人绒毛膜促性腺激素升高6例临床特点
- Author:
Yan LV
1
;
Feng-Zhi FENG
;
Yang XIANG
;
Xi-Run WAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院妇产科
- Keywords:
human chorionic gonadotropin;
gestational trophoblastic disease;
chemotherapy
- From:
Medical Journal of Peking Union Medical College Hospital
2015;(3):212-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and significance of diagnosis and treat -ment associated with persistent real low-level elevation of human chorionic gonadotropin ( hCG) .Methods Six patients diagnosed with persistent real low-level hCG elevation at Peking Union Medical College Hospital in the period from August 2011 to March 2015 were collected .Clinical records of the 6 patients were reviewed to retro-spectively analyze clinical features , diagnosis and treatment approaches , and follow-up results.Results Among the 6 patients , 3 were secondary to uterine curettage for hydatidiform moles , and the other 3 had received chemo-therapy for invasive moles , in whom the median chemotherapy cycle number was 8 and all experienced failure of at least one chemotherapy regimen .The median follow-up time was 24 months.The median period between the termination of treatment and the initial low-level hCG elevation was 5.5 months.The median duration of low-level hCG elevation was 16.5 months.Four patients had no evidence of progression , 1 patient progressed to choriocar-cinoma, and 1 presented with the hCG level decreasing to the normal range after spontaneous delivery .Conclu-sion Persistent real low-level hCG elevation may persist for a long time and not respond to chemotherapy .Long-term close monitoring is necessary , but treatment is not recommended .
