Analysis of clinical characteristics and drug resistance genes of children infection with Bordetella pertussis and Mycoplasma pneumoniae in Tacheng region of Xinjiang province in the latter half of 2023
10.3760/cma.j.issn.1673-4912.2024.11.007
- VernacularTitle:2023年下半年新疆塔城地区儿童百日咳鲍特菌及肺炎支原体感染临床特点及耐药基因分析
- Author:
Huang RONG
1
;
Li PAN
;
Jinhua LIU
;
Xiaohua LIU
;
Tao ZHANG
Author Information
1. 中国医科大学附属塔城地区人民医院儿科834700
- Keywords:
Bordetella pertussis;
Mycoplasma pneumoniae;
Children;
Respiratory tract infection;
Drug resistance gene
- From:
Chinese Pediatric Emergency Medicine
2024;31(11):836-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics and drug resistance genes of Bordetella pertussis（B.P）and Mycoplasma pneumoniae（MP）infection in children in Tacheng，Xinjiang Province in the latter half of 2023 .Methods:We retrospectively collected etiological detection results and clinical data of children with respiratory tract infection from 4 medical institutions in Tacheng area from July 1，2023 to December 31，2023，the B.P and MP infection groups were selected for comparative analysis.Targeted next-generation sequencing was used to detect the pathogens and their drug resistance-related gene mutations.Results:A total of 193 cases were included in the study，including 127 MP cases and 66 B.P cases.Statistical analysis showed that the age of the B.P group was significantly younger than that of the MP group，and the proportion of minority patients was significantly higher in the B.P group.All 191（98.9%）patients with cough symptom and 114（59.0%）with fever symptom.The indices of white blood cell，C-reactive protein，procalcitonin and erythrocyte sedimentation rate in the two groups were basically normal，and there was no statistical difference（ P>0.05）.A total of 103 MP strains were detected positive with drug resistance gene，all of which were A2063G mutation.While only 13 strains were detected positive in the B.P group，accounting for 19.6%. Conclusion:MP and B.P are the most common pathogens causing respiratory infections in children in Tacheng recently.The clinical symptoms are mainly cough and fever in older children，there is no significant difference in white blood cell，C-reactive protein，procalcitonin and erythrocyte sedimentation rate in the early stage of the disease，and it is difficult to distinguish.The drug-resistant mutation rate of MP strain is higher in this region，while the mutation rate of B.P strain is lower.
