Research progress on neutralizing antibodies for the treatment of severe respiratory syncytial virus infection in children

VernacularTitle:中和抗体治疗儿童重症呼吸道合胞病毒感染的研究进展
Author: Yuan GAO ¹ ; Jiujun LI
Author Information

1. 中国医科大学附属盛京医院儿内科，沈阳　110004
Keywords: Neutralizing antibody; Respiratory syncytial virus; Virus pneumonia; Severe; Children
From: Chinese Pediatric Emergency Medicine 2024;31(5):363-366
CountryChina
Language:Chinese
Abstract: Respiratory syncytial virus（RSV）is the leading cause of severe lower respiratory tract infections in young children，with a high rate of hospitalization and mortality.Specific anti-RSV therapies have not been reported.The structure of RSV is such that it is mainly F and G proteins in the surface that act as adhesion and invade the host cells.Therefore，monoclonal antibodies against F and G proteins with neutralization sites are currently being developed. This review summarized the mechanism, prevention and treatment of RSV based on neutralizing antibody.