EVI1 expression, clinical and cytogenetical characteristics in 447 patients with acute myeloid leukemia
10.3760/cma.j.issn.0253-2727.2016.11.002
- VernacularTitle:447例急性髓系白血病患者EVI1基因表达、临床和细胞遗传学特征研究
- Author:
Xuefeng HE
1
;
Qinrong WANG
;
Jiannong CEN
;
Huiying QIU
;
Aining SUN
;
Suning CHEN
;
Depei WU
Author Information
1. 215006,苏州大学附属第一医院、江苏省血液研究所、卫生部血栓与止血重点实验室、血液学协同创新中心
- Keywords:
Gene,EVI1;
Leukemia,myeloid,acute;
Chromosome aberations;
Mutation
- From:
Chinese Journal of Hematology
2016;37(11):936-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447 acute myeloid leukemia (AML) patients.Methods EVI1 expressions were measured in 447 AML cases from Jan.2007 to Apr.2015 to couple with clinical,cytogenetic and mutations' characteristics to summarize the features of AMLs with high EVI1 expression.Results 17.9％ of AML were high EVI1 expression (EVI1 +),and the remainder low EVI1 expression (EVI1-).No significant differences between the two groups in terms of age,sex,hemoglobin level,white blood cell count and platelet count were observed.More M0,M5 and M6 subtypes were observed in EVI1 + group (P=0.027,0.004 and 0.011,respectively).Cytogenetic abnormalities of 1 lq15,1 1q23/MLL,3q26,-7/7q-and t(9;11) were observed more frequently in EVI1 + group (P＜0.001,＜0.001,＜0.001,＜0.001,=0.014,respectively).Normal karyotype,inv(16),t(8;21) were observed more frequent in EVI1-group(P=0.001,0.009,0.002,respectively).EVI1 + was more observed in high risk cytogenetics.Mutation of NPM1 was more observed in EVI1-group (P ＜ 0.001).Remission rate in EVI1 + group was significantly lower than EVI1-group (P＜0.001).Leukemia-free survival was improved in EVI1 + AML patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).Conclusions High EVI1 expression was more observed in FAB subgroup M5,harbored more cytogenetic abnormalities of 1 1p15,1 1q23/MLL,3q26 rearrangement,-7/7q-and t (9;11).Remission rate of high EVI 1 expression AML was lower,which could be improved by allo-HSCT.
