Research progresses on the role of programmed cell death in the inflammatory response of chronic refractory wounds
10.3760/cma.j.cn501225-20240123-00029
- VernacularTitle:程序性细胞死亡在慢性难愈合创面炎症反应中的作用研究进展
- Author:
Xuelian CHEN
1
;
Yan LIU
Author Information
1. 上海交通大学医学院附属瑞金医院灼伤整形科，上海市烧伤研究所，上海 200025
- Keywords:
Wound healing;
Inflammation;
Chronic refractory wounds;
Programmed cell death;
Damage-associated molecular patterns
- From:
Chinese Journal of Burns
2024;40(10):991-995
- CountryChina
- Language:Chinese
-
Abstract:
Continuous inflammatory response and repeated tissue damage lead to a chronic inflammatory state that is an important pathological feature of chronic refractory wounds, and plays an important pathogenic role in the occurrence and development of chronic refractory wounds. Multiple types of programmed cell death can release damage-associated molecular patterns, and trigger or induce sustained inflammatory responses, leading to dysregulated tissue repair. This review will outline the known role of programmed cell death in the inflammatory response of chronic refractory wounds from the perspective of generating damage-associated molecular patterns, and explore possible research directions on the role and mechanism of programmed cell death in chronic refractory wounds.
