Research advances on the mechanism of dendritic epidermal T lymphocytes in wound healing
10.3760/cma.j.cn501120-20200226-00092
- VernacularTitle:树突状表皮T细胞在创面愈合中作用机制的研究进展
- Author:
Jue WANG
1
;
Xiaorong ZHANG
;
Weifeng HE
;
Guangping LIANG
Author Information
1. 陆军军医大学（第三军医大学）第一附属医院全军烧伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆市疾病蛋白质组学重点实验室 400038
- Keywords:
T-lymphocytes;
Wound healing;
Dendritic epidermal T lymphocytes;
Epidermal homeostasis;
Re-epithelialization
- From:
Chinese Journal of Burns
2021;37(3):296-300
- CountryChina
- Language:Chinese
-
Abstract:
Wound healing is a complex and critical process, which includes three stages: inflammation, proliferation, and remodeling. The epidermal cells are precisely regulated in this process. On one hand, keratinocytes around the wound edge migrate and proliferate to form a new basement membrane to cover the wound. On the other hand, the epidermal stem cells are activated with the proliferation and differentiation being enhanced, and the terminal differentiation and apoptosis being inhibited; and together with keratinocytes, epidermal stem cells promote the process of re-epithelialization under the regulation of various factors. In the epidermis, there is a group of resident T cell subsets, dendritic epidermal lymphocytes (DETCs) that play a key role in protecting the function of epidermal tissue. DETCs are activated after recognizing unknown antigens, the activated DETCs secret cytokines such as insulin-like growth factor Ⅰ, keratinocyte growth factor-1/2, granulocyte-macrophage colony stimulating factor, interferon-γ, and transforming growth factor-β, which promote epidermal homeostasis and re-epithelialization by regulating the dynamic balance among keratinocytes migration, proliferation, and apoptosis, and the differentiation of epidermal stem cells around the wound edge. This article discusses the biological characteristics of DETCs and their roles in the maintenance of epidermal homeostasis and wound healing.
