Analysis of influencing factors of recurrent wheezing in children with bronchopneumonia and construction of prediction model
10.11958/20231879
- VernacularTitle:支气管肺炎患儿反复喘息的影响因素分析及预测模型构建
- Author:
Lei WANG
1
;
Kun MENG
;
Bing WANG
Author Information
1. 淮南阳光新康医院儿科(邮编 232000)
- Keywords:
bronchopneumonia;
influencing factor analysis;
diagnosis,identification;
risk factor;
recurrent wheezing
- From:
Tianjin Medical Journal
2024;52(8):850-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical influencing factors of recurrent wheezing in children with bronchopneumonia,and construct a risk prediction model.Methods A total of 155 children with bronchopneumonia were divided into the recurrent wheezing group(47 cases)and the non-recurrent wheezing group(108 cases)according to the occurrence of recurrent wheezing within 1 year after discharge.General clinical data,including the length of hospital stay,total course of disease,history of eczema,history of other personal allergies(food allergy history,drug allergy history,allergic rhinitis history and allergic dermatitis history),family history of allergies,living environment,frequency of colds and exposure to allergens,and laboratory indexes[T lymphocyte subsets,eosinophils(EOS),25-hydroxy vitamin D3 and total immunoglobulin E(IgE)]were compared between the 2 groups.Multivariate Logistic regression analysis was conducted to identify influencing factors of recurrent wheezing,and a risk prediction model was constructed.Homser-Lemeshow tested the goodness of fit of the model.The predictive performance of the model was evaluated using the receiver operating characteristic(ROC)curve.Results Compared with the non-recurrent wheezing group,the proportions of children with history of other personal allergies,EOS positivity(>9%),vitamin D insufficiency(＜30 μg/L)and total IgE positivity(>60 IU/mL)were higher in the recurrent wheezing group(P＜0.05).Multivariate Logistic regression analysis showed that history of personal allergies,EOS positive,vitamin D insufficiency and total IgE positive were independent risk factors for recurrent wheezing in children with bronchopneumonia(P＜0.05).Homser-Lemeshow showed that prediction model had goodness of fit(χ2=3.055,P=0.692).The model predicted that the area under curve for recurrent wheezing was 0.816,sensitivity and specificity of the model for predicting recurrent wheezing were 70.21%and 80.56%,respectively.Conclusion The prediction model constructed based on history of personal allergies,EOS positive,vitamin D insufficiency and total IgE positive has good predictive performance for recurrent wheezing in children.
