Mechanism and Strategy of CAR-T Cell Therapy for T Cell Exhaustion in Tumor
10.3870/j.issn.1672-0741.23.11.008
- VernacularTitle:CAR-T细胞治疗肿瘤中T细胞耗竭现象的作用机制和策略
- Author:
Xinpei MO
1
;
Yan LI
;
Yong DUAN
Author Information
1. 云南检验医学重点实验室;中国云南省检验医学临床研究中心;昆明医科大学第一附属医院临床实验室与诊断创新团队,昆明 650032
- Keywords:
CAR-T;
T-cell depletion;
cancer;
immunotherapy
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(5):705-712
- CountryChina
- Language:Chinese
-
Abstract:
CAR-T cell immunotherapy,which is derived from T cells and employed in various diseases,particularly blood disorders,involves in vitro gene modification and infusion for treatment.Despite the significant therapeutic effects of CAR-T cells,challenges such as side effects,toxicity,CAR-T cell exhaustion,the immunosuppressive tumor microenvironment,and ge-netic alterations exist.The clinical efficacy of CAR-T cells in solid tumor treatment is limited,often leading to patient re-lapse.Addressing CAR-T-cell exhaustion remains a significant challenge.Scientists are employing diverse technical approaches to prevent CAR-T-cell exhaustion to increase the reliability and utility of CAR-T-cell therapy.This article delves into the mech-anisms of T-cell depletion and CAR-T-cell exhaustion,along with strategies to alleviate or disrupt CAR-T-cell exhaustion.This review of research progress on CAR-T-cell exhaustion aims to identify optimal strategies for reversing CAR-T-cell function and provide a comprehensive theoretical foundation for enhancing CAR-T-cell therapy technology.
