Gut Microecology and Neurologic Autoimmune Diseases
10.3870/j.issn.1672-0741.23.11.003
- VernacularTitle:肠道微生态与神经系统自身免疫性疾病
- Author:
Jinyi YAN
1
;
Zhijun LI
Author Information
1. 华中科技大学同济医学院附属同济医院神经内科,武汉 430030
- Keywords:
neurologic autoimmune disease;
gut microbiota;
microbe-gut-brain axis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(4):539-544
- CountryChina
- Language:Chinese
-
Abstract:
Neurologic autoimmune diseases are a group of disorders in which the immune system attacks the nervous sys-tem resulting in dysfunctional impairments.The role of gut microbiota in the development of neurologic autoimmune diseases has gained widespread attention in recent years.The development of autoimmune diseases is often accompanied by intestinal flo-ra disorders and microbial metabolite abnormalities.Disturbances of the intestinal flora are characterized by changes in the diver-sity and composition of the flora,as well as an increase in pathogens.When intestinal microecological imbalances result in unsuc-cessful maintenance of immune homeostasis,they may be involved in the development of various autoimmune diseases through diverse mechanisms such as neural pathways,endocrine,and immune-inflammatory networks.This article reviews the relation-ship between common neurologic autoimmune diseases(such as multiple sclerosis,optic neuromyelitis optica spectrum disorders,autoimmune encephalitis,myasthenia gravis,Guillain-Barré syndrome,and chronic Guillain-Barré syndrome)and gut microbiota,and explores future therapeutic approaches for neurologic autoimmune diseases that may involve the gut microbiota.
