Research progress on the role and mechanism of PANoptosis in liver diseases

VernacularTitle:泛凋亡在肝脏疾病中的作用及其机制研究进展
Author: Liying MIAO ¹ ; Xin WANG ; Yangyang HAN
Author Information

1. 新疆医科大学基础医学院生物学教研室，乌鲁木齐　830017
Keywords: Programed cell death; PANoptosis; Liver-related disease; Pathogenesis
From: Chinese Journal of Hepatology 2024;32(11):1047-1052
CountryChina
Language:Chinese
Abstract: Pyroptosis, apoptosis, and necroptosis are three key types of pathways in programmed cell death (PCD). Studies have found a wide range of cross-talk between the three types of pathways, leading to the proposal of the concept of PANoptosis, or the inflammatory PCD pathway regulated by the PANoptosome complex, which has key features of pyroptosis, apoptosis, and/or necroptosis that cannot be explained by any of these single pathways. A growing number of studies have discovered that PANoptosis is involved in many liver-related disease processes, including liver cancer, metabolic-associated fatty liver disease, liver failure, fulminant viral hepatitis, and others. Therefore, this paper reviews the potential mechanism and role of PANoptosis in order to provide directions for studying the pathogenesis and potential therapeutic strategies for a variety of liver-related diseases.