Revealing research progress for immunological characteristics of chronic hepatitis B applying single-cell RNA sequencing technology
10.3760/cma.j.cn501113-20240426-00230
- VernacularTitle:应用单细胞转录组测序技术揭示慢性乙型肝炎免疫学特征的研究进展
- Author:
Chang SHU
1
;
Dazhi ZHANG
Author Information
1. 重庆医科大学附属第二医院感染科 重庆医科大学感染性疾病分子生物学教育部重点实验室 重庆医科大学病毒性肝炎研究所，重庆 401336
- Keywords:
Chronic hepatitis B;
Single-cell RNA sequencing;
Pathogenesis;
Immune characteristics;
Diagnosis
- From:
Chinese Journal of Hepatology
2024;32(11):1042-1046
- CountryChina
- Language:Chinese
-
Abstract:
Chronic hepatitis B (CHB) is one of the major public health problems worldwide. The potential immunological mechanisms of hepatitis B virus (HBV) infection has not yet been clearly studied. Single-cell RNA sequencing (scRNA-seq) technology, as an emerging sequencing method in recent years, can provide a high-throughput view of the whole transcriptome at the single-cell level, reveal subtle changes in transcriptional profiles of immune cells during the course of chronic hepatitis B, and provide technological support for exploring the immunopathogenesis and potential therapeutic targets for CHB. This article summarizes the research progress conducted on scRNA-seq technology in order to provide novel therapeutic ideas for the immunological characteristics of chronic hepatitis B.
