Research progress of SP/NK-1R system in breast cancer

VernacularTitle:SP/NK-1R系统在乳腺癌中的研究进展
Author: Yuming SHAO ¹ ; Kunbing ZHU ; Jie ZHANG
Author Information

1. 青岛大学附属山东省妇幼保健院乳腺甲状腺外科(济南 250000)
Keywords: Breast cancer; Substance P/Neurokinin 1 receptor system; Neurokinin 1 receptor antagonist; Targeted therapy
From: Practical Oncology Journal 2024;38(4):268-272
CountryChina
Language:Chinese
Abstract: In recent years,although many advances have been made in the treatment of breast cancer,its incidence is still on the rise,and the search for new drug targets and biomarkers has become a research hotspot.More and more clinical studies are paying attention to the interaction between tumor cells and tumor microenvironment,and it is believed that tumor microenvironment plays a crucial role in the progression of malignant tumors.Substance P(SP)can participate in the process of carcinogenesis and play a crucial key role in maintaining the tumor microenvironment.Neurokinin 1 receptor(NK-1R)is expressed in the cytoplasm of tumor cells and is significantly associated with many tumor characteristics.SP induces tumor cell proliferation,angiogenesis and migration through its receptor NK-1R,and exerts anti-apoptotic effects.In future treatment plan,whether NK-1R antagonists can be used to provide more accurate targets for the diagnosis and treatment of breast cancer has become a hot topic.This article reviews the research status of SP/NK-1R system in breast cancer.