Research progress of Claudin family proteins in inflammatory bowel disease and colitis associated colorectal cancer
10.11904/j.issn.1002-3070.2024.03.010
- VernacularTitle:Claudin家族蛋白在炎症性肠病及肠炎相关性结直肠癌中的研究进展
- Author:
Ruizhi ZENG
1
;
Yongqiang LI
Author Information
1. 广西医科大学附属肿瘤医院消化肿瘤内科(南宁 530021)
- Keywords:
Claudin protein;
Inflammatory bowel disease;
Colorectal cancer associated with enteritis;
Intestinal barrier;
Tight junction protein
- From:
Practical Oncology Journal
2024;38(3):207-212
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the generation,maintenance and regulation of the intestinal mucosal barrier have become a re-search focus in the occurrence,development,treatment,and prognosis of inflammatory bowel disease(IBD)and colitis associated color-ectal cancer(CAC).Tight junction(TJ)proteins are an important component of the intestinal mucosal barrier,which the Claudin fami-ly proteins have become a research hotspot.This review mainly introduces the changes of Claudin protein in IBD and CAC,as well as the latest research progress on its role in the occurrence,development and clinical treatment of IBD and CAC.
