Research progress on the mechanism of action of heme oxygenase-1 regulating ferroptosis in non-alcoholic fatty liver disease
10.3760/cma.j.cn501113-20240223-00089
- VernacularTitle:血红素加氧酶1调控铁死亡对非酒精性脂肪性肝病的作用机制研究进展
- Author:
Xiwei YUAN
1
;
Yuemin NAN
Author Information
1. 河北医科大学第三医院中西医结合肝病科，河北省慢性肝病肝纤维化机制研究重点实验室，石家庄 050051
- Keywords:
Non-alcoholic fatty liver disease;
Heme oxygenase-1;
Ferroptosis
- From:
Chinese Journal of Hepatology
2024;32(3):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) has gradually become the most prevalent chronic liver disease in the world, but its pathogenesis has not been fully elucidated. Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation. Heme oxygenase-1 is a recognized antioxidant enzyme and an important regulatory factor in ferroptosis that modulates ferroptosis through various pathways and, in turn, regulates NAFLD. This paper reviews the regulatory mechanism of heme oxygenase-1 on NAFLD in ferroptosis pathway, with a view to clarifying the occurrence and development mechanisms of NAFLD and providing new vision and targets for its prevention and treatment.
