Research progress of non-coding RNA-encoding polypeptides in primary hepatocellular carcinoma
10.3760/cma.j.cn501113-20231126-00236
- VernacularTitle:非编码RNA编码多肽在原发性肝细胞癌中的研究进展
- Author:
Dongmei CHEN
1
;
Zhou YU
;
Zewei ZHANG
;
Jinlan HUANG
Author Information
1. 福建医科大学附属第一医院检验科，福州 350005
- Keywords:
Hepatocellular carcinoma;
Non-coding RNA;
Open reading frame;
Polypeptides
- From:
Chinese Journal of Hepatology
2024;32(1):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, with rapid progression and a poor prognosis. More and more studies have shown that there are small open reading frames (sORFs) on the molecular sequences of a large number of non-coding RNAs (ncRNAs), which can encode conserved peptides that play an important role in controlling the occurrence and development of HCC. This article introduces the discovery, prediction, and validation methods of ncRNA-encoding polypeptides and reviews its research progress, with the aim of providing new targets and ideas for early-stage diagnosis, targeted therapy, and prognosis assessment of HCC.
