Research progress and clinical application value of exosomal circRNAs in hepatocellular carcinoma

VernacularTitle:外泌体circRNAs在肝癌中的研究进展及临床应用价值
Author: Chunfei LI ¹ ; Yankun LIU ; Yufeng LI
Author Information

1. 华北理工大学研究生院，唐山　063200
Keywords: Hepatocellular carcinoma; Exosomes; Circular RNAs
From: Chinese Journal of Hepatology 2022;30(11):1248-1252
CountryChina
Language:Chinese
Abstract: Primary liver cancer (hereinafter referred to as HCC) is the sixth most common type of cancer and the third leading cause of cancer-related mortality worldwide. Since patients in the early stage of HCC are typically asymptomatic and there are currently no specific detection methods for the early stage of HCC, the majority of patients are diagnosed in the late stage. Exosomes carry proteins, non-coding RNAs, such as cyclic RNAs (circRNAs), and other biological molecules. Patients with hepatocellular carcinoma have a higher concentration of serum exosomes than healthy individuals, and the circRNAs in the exosomes can reflect the source cells and real-time disease status, suggesting it has the potential to detect liver cancer early. This paper focuses on the latest progress of exosomal circRNAs and analyzes the potential value of exosomes in the early diagnosis, treatment, and progression of HCC.