Research progress of mast cell-derived exosomes in bronchial asthma
10.3969/j.issn.1006-5725.2024.15.026
- VernacularTitle:肥大细胞来源的外泌体在支气管哮喘中的研究进展
- Author:
Jiao XU
1
;
Min ZHANG
;
Guo-Gang XIE
Author Information
1. 常州市武进人民医院呼吸与危重症医学科(江苏常州 213017)
- Keywords:
exosomes;
mast cells;
bronchial asthma
- From:
The Journal of Practical Medicine
2024;40(15):2194-2198
- CountryChina
- Language:Chinese
-
Abstract:
Carrying the pan-mast cell markers IgE immunoglobulin high-affinity receptor(FcεRI)and SCF receptor c-kit,mast cell-derived exosomes are rich in sphingomyelin,lipid-associated proteins,and loaded with MHC-Ⅱ molecules and transfer functional mRNAs and miRNAs to the receptor of CD34+progenitor cells and mast cells.Activated mast cell-derived exosomes contain a large number of functional mast cell-specific mediators and may vary in size,protein,lipid,RNA and DNA contents.Mast cell exosomes can recruit B cells and T cells to the lungs,regulating immune and inducing the activation of other asthma-related cells.Also,mast cell-derived exosomes interact with airway smooth muscle cells and induce the release of pro-inflammatory cytokines,allowing asthma symptoms to persist.Immune complexes(IgE and antigens)present on mast cell-derived exosomes exacer-bate local allergic reactions by a self-amplification mechanism meanwhile deliver antigens to other immune cells.Mast cell-derived exosomes may be potential targets for the treatment of bronchial asthma,and their purification and optimization be needed further to research.This article will review the mechanism of mast cell-derived exosomes in bronchial asthma,so as to provide new ideas for the prevention and treatment of bronchial asthma.
