Research progress in T cell exhaustion and its relationship with respiratory diseases
10.3969/j.issn.1006-5725.2024.13.023
- VernacularTitle:T细胞耗竭与呼吸系统疾病关系的研究进展
- Author:
Ziqi DING
1
;
Qian ZHANG
Author Information
1. 南京医科大学附属常州第二人民医院呼吸与危重症医学科(江苏常州 213164)
- Keywords:
T cell exhaustion;
inhibitory receptors;
respiratory diseases;
immunotherapy
- From:
The Journal of Practical Medicine
2024;40(13):1895-1900
- CountryChina
- Language:Chinese
-
Abstract:
T cell exhaustion occurs mostly in chronic infections,cancers and autoimmune diseases.Continuous antigenic stimulation leads to the generation of exhausted T cells,which is characterized by progressive loss of effector function,continuous high expression of inhibitory receptors,transcription and epigenetic changes,and metabolic disorders.The in-depth study of the specific mechanism of T cell exhaustion is providing new ideas for the immunotherapy of chronic infection,lung cancer and chronic airway inflammatory disease in respiratory dis-eases.This paper discussed the influencing factors and characteristics of T cell exhaustion and reviewed the current research status of T cell exhaustion and respiratory diseases.
