Effects of sevoflurane and propofol on perioperative HIF-1α levels and postoperative recovery in patients undergoing bariatric surgery
10.3969/j.issn.1006-5725.2024.11.015
- VernacularTitle:七氟烷与丙泊酚对减重手术患者围术期低氧诱导因子-1α的变化及术后康复的影响
- Author:
Shan'e DUAN
1
;
Mingzhu ZHONG
;
Qingde ZHANG
;
Xuemei PENG
Author Information
1. 暨南大学附属第一医院麻醉科(广州 510630)
- Keywords:
sevoflurane;
propofol;
HIF-1α
- From:
The Journal of Practical Medicine
2024;40(11):1554-1559
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to investigate the differential effects of sevoflurane and propofol on perioperative HIF-1α levels and postoperative recovery in patients undergoing bariatric surgery.Methods A total of 40 obese patients(BMI≥44 kg/m2)were randomly allocated into two groups:sevoflurane(n=21)group and propofol(n=19)group.The quantitative measurement of HIF-1α levels in human serum at different time points was conducted using ELISA.The assessment of redness,swelling,pain,exudation,and prognosis-related indicators of the patient's umbilical incision was performed at 24 and 48 hours after surgery.Results On the day following surgery,there was a significant increase in HIF-1α levels in the sevoflurane group and a significant decrease in the propofol group.The frequency and type of opioid analgesics used in the sevoflurane group were signifi-cantly lower than those used in the propofol group after surgery.Conclusions Compared with propofol,sevoflurane is more suitable for maintaining anesthesia in obese patients undergoing bariatric surgery.Sevoflurane can promote enhanced recovery after surgery by reducing postoperative analgesic consumption and upregulating HIF-1α levels.
