Application of Mdr2 gene knockout mice in liver disease research
10.3760/cma.j.cn501113-20191007-00364
- VernacularTitle:Mdr2基因敲除小鼠在肝病研究中的应用
- Author:
Meng LI
1
;
Jian PING
;
Lieming XU
Author Information
1. 上海中医药大学附属曙光医院 201203
- Keywords:
Hepatic fibrosis;
Liver cancer;
Primary sclerosing cholangitis;
Animal model
- From:
Chinese Journal of Hepatology
2021;29(6):585-590
- CountryChina
- Language:Chinese
-
Abstract:
Mdr2 knockout mice is a liver disease model, which causes cholestasis due to the lack of phospholipids in the bile. At present, it is not only used for the study of human homologous MDR3 gene, but also widely used as an animal model of liver diseases such as primary sclerosing cholangitis, liver fibrosis, progressive familial intrahepatic cholestasis, liver cancer. Herein, we review the Mdr2 knockout mice physiological characteristics and its application in liver disease research.
