Research progress on hepatotoxicity of acetaminophen

VernacularTitle:对乙酰氨基酚肝毒性的研究进展
Author: Ting HU ¹ ; Wenqi HUANG ; Hang SUN
Author Information

1. 重庆医科大学附属第二医院病毒性肝炎研究所　400010
Keywords: Hepatotoxicity; Acetaminophen; Biomarker; Mitochondrial damage; Mitophagy
From: Chinese Journal of Hepatology 2021;29(3):279-283
CountryChina
Language:Chinese
Abstract: Acetaminophen (APAP) is a widely used antipyretic and analgesic drug that is safe and effective in the therapeutic doses, but overdose may cause hepatotoxicity and even acute liver failure (ALF). Finding reliable biomarkers for APAP toxicity is not only a hot spot of current research, but also a problem that needs to be solved urgently. Clinicians should consider the existence of APAP hepatotoxicity when using APAP treatment, and explain that APAP may have a certain degree of dose dependence. This paper reviews the most promising biomarkers currently being evaluated, and expounds their application in the field of APAP hepatotoxicity, as well as the mechanism of mitochondrial damage and mitochondrial autophagy, thereby contributing to the diagnosis, prognosis, mechanism and research progress of therapeutic targets of APAP hepatotoxicity.