Effect of hyperuricemia on fasting blood glucose level in retired cadres in Shenyang based on longitudinal physical examination data
10.16753/j.cnki.1008-2344.2024.05.004
- VernacularTitle:基于纵向体检数据探讨高尿酸血症对沈阳市离退休干部空腹血糖水平的影响
- Author:
Yao MU
1
;
Zhuo LI
;
Song HAN
;
Ying ZHANG
Author Information
1. 沈阳医学院公共卫生学院流行病学教研室,辽宁 沈阳 110034
- Keywords:
retired cadres;
hyperuricemia;
fasting blood glucose;
diabetes mellitus;
repeated measurement;
generalized estimating equations
- From:
Journal of Shenyang Medical College
2024;26(5):465-468,513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of hyperuricemia(HUA)on fasting blood glucose(FBG)level in retired cadres in Shenyang by using generalized estimating equations(GEE).Methods:Data of demographic characteristics and clinical indicators of retired cadres who underwent physical examination in Central Hospital Affiliated to Shenyang Medical College for 3 consecutive years from Sep 2013 to Sep 2015 were collected.According to serum uric acid(SUA)level in the first physical examination,the subjects were divided into HUA group and SUA normal group.GEE was used to analyze the effect of HUA on FBG level.Results:Body mass index(BMI)in HUA group was higher than that in SUA normal group during the three years,and the difference in FBG level between 2013 and 2015 was statistically significant(P＜0.05).After adjusting the physical examination time,gender,and age by GEE(Model 1),the FBG level in HUA group was significantly higher than that in SUA normal group(OR=2.158,95%CI:1.192-3.908,P=0.011).After further adjusting for confounding factors such as BMI,alcohol consumption,family history of diabetes mellitus(DM),hyperlipidemia,and hypertension(Model 2),the FBG level between the two groups was still significantly different(OR=1.788,95%CI:1.003-3.185,P=0.049).Conclusion:HUA can increase FBG level in the elderly population,and the risk is increased by 1.788 times compared with SUA normal group,suggesting that HUA is related to FBG level,which provides a reference for further exploration of the etiology of DM and provides a basis for effective prevention of DM.
