Autophagy in the liver failure
10.3760/cma.j.cn501113-20190803-00288
- VernacularTitle:细胞自噬与肝功能衰竭
- Author:
Hongrui XU
1
;
Xin WANG
;
Yadong WANG
;
Chuan SHEN
;
Caiyan ZHAO
Author Information
1. 河北医科大学第三医院肝病感染科，石家庄 050051；河南大学淮河医院，开封 475000
- Keywords:
Cell autophagy;
Liver failure;
Apoptosis;
Necrosis;
SIRT1
- From:
Chinese Journal of Hepatology
2020;28(12):1069-1072
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a severe liver disease syndrome, with massive or sub-massive liver tissues necrosis, and it develops rapidly, with poor clinical prognosis and high mortality. In recent years, autophagy role in the liver failure has received increasing attention. The study of the role of regulatory mechanism of autophagy is of great significance for the in-depth study of the prevention and treatment of liver failure. Based on the research progress of liver failure at home and abroad, this paper explores and summarizes the relationship between autophagy with necrosis and apoptosis, as well as the mechanism and expression level of autophagy in each stage of liver failure, with hope to provide reference for the in-depth research and clinical treatment of liver failure.
