Advances in the regulation of functions of hepatic stellate cells by exosomes
10.3760/cma.j.cn501113-20190412-00123
- VernacularTitle:外泌体调控肝星状细胞功能的研究进展
- Author:
Qiannan YE
1
;
Jian PING
;
Lieming XU
Author Information
1. 上海中医药大学附属曙光医院 201203；上海中医药大学肝病研究所 201203
- Keywords:
Exosomes;
Hepatic stellate cells;
Activation;
Migration;
Apoptosis;
Autophagy
- From:
Chinese Journal of Hepatology
2020;28(11):981-984
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are small vesicles with a bilayer membrane structure secreted by a variety of cells. They are widely distributed in a variety of body fluids and contain proteins, nucleic acids and other components. They can mediate information transmission between cells and participate in a variety of physiological and pathological activities of cells. Hepatocytes, hepatic sinus endothelial cells and other cells were able to communicate with hepatic stellate cells via exosomes, and regulate the activation, migration, apoptosis and other biological activities of hepatic stellate cells. In this review, the recent advances in the regulation of exosomes on the biological activity of hepatic stellate cells were reviewed.
