The value of PET/CT combined with serum LDH,β2-MG and CRP in the differential diagnosis of sarcoidosis and lymphoma
10.3969/j.issn.1002-1671.2024.12.024
- VernacularTitle:PET/CT联合血清LDH、β2-MG 及 CRP对结节病与淋巴瘤的鉴别诊断价值
- Author:
Bin HU
1
;
Liu HE
;
Huan ZHANG
;
Cheng GU
;
Xinyu SHEN
;
Xiaoming ZHANG
;
Lichun ZHENG
Author Information
1. 唐山市工人医院核医学科,河北 唐山 063000;河北医科大学研究生学院,河北 石家庄 050000
- Keywords:
sarcoidosis;
lymphoma;
18 F-fluorodeoxyglucose;
positron emission tomography/computed tomography;
hematological indicators
- From:
Journal of Practical Radiology
2024;40(12):2037-2040,2070
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differential diagnostic value of 18F-fluorodeoxyglucose(18F-FDG)/PET/CT combined with serum lactate dehydrogenase(LDH),β2-microglobulin(β2-MG),and C-reactive protein(CRP)in sarcoidosis and lymphoma.Methods The 18F-FDG PET/CT images of 19 patients with sarcoidosis and 33 patients with lymphoma were analyzed retrospectively.The lymph node maximum diameter,density,distribution morphology,maximum standardized uptake value(SUVmax),extra-nodal involvement,and serum LDH,β2-MG,and CRP results were analyzed and compared.Results There was no statistically significant difference between sarcoidosis and lymphoma in lymph node density,necrosis rate,and SUVmax(P＞0.05).There was statistically significant difference in the maximum diameter between lymph nodes in sarcoidosis(2.4±0.7)cm and lymphoma(3.3±1.3)cm(P＜0.05).The incidence of symmetric enlargement of mediastinal and hilar lymph nodes was 84.2％in sarcoidosis,the lymph node fusion rate was 21.1％,the lung involvement rate was 57.8％,the spleen involvement rate was 10.5％,and the rates of lymphoma were 15.2％,63.6％,0.0％,and 36.4％,with statistically significant differences(P＜0.05).There were statistically significant differences in LDH and β2-MG between the two groups(P＜0.05),but the differences in CRP were not statistically significant(P＞0.05).Conclusion PET/CT can show the anatomy of mediastinal and hilar lymph nodes and extra-nodal affected organs as well as glucose metabolism,showing a certain differential diagnostic value of sarcoidosis and lymphoma when combined with serum LDH and β2-MG levels.
