Multilayer brain functional network in patients with chronic subjective tinnitus
10.3969/j.issn.1002-1671.2024.12.001
- VernacularTitle:慢性主观性耳鸣患者的多层脑功能网络研究
- Author:
Yuan FENG
1
;
Xiaomin XU
;
Biao LI
;
Xindao YIN
;
Yuchen CHEN
Author Information
1. 南京医科大学附属南京医院 南京市第一医院医学影像科,江苏 南京 210006
- Keywords:
chronic subjective tinnitus;
brain function;
multilayer network;
anterior cingulate gyrus;
hippocampus
- From:
Journal of Practical Radiology
2024;40(12):1937-1940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate and analyze the resting-state MRI data of patients with chronic subjective tinnitus via the multilayer brain functional network and to find the relevant node parameters with certain dynamic characteristics.Methods A total of 28 chronic subjective tinnitus patients(tinnitus group)and 39 sex,age,and education-matched healthy volunteers(control group)were included.After completing relevant otologic and neuropsychiatric tests for all subjects,3.0T MRI data were collected.Data preprocessing,dynamic functional connection analysis,multilayer modularization and network switching rate were performed.Correlation analysis between MRI data results and clinical data were further conducted.Results There was no significant difference in terms of Q between tinnitus group and control group(P＞0.05).Compared with the control group,the network switching rate of bilateral anterior cingulate gyrus(P＜0.001)and right hippocampus(P＜0.01)was significantly decreased in the tinnitus group.Additionally,the network switching rate of right hippocampus was negatively correlated with the duration of tinnitus(r=-0.503,P=0.006).Conclusion Based on using multilayer brain functional network method,the signal regulations in anterior cingulate gyrus and hippocampus in chronic subjective tinnitus patients is changed,while the alteration of hippocampus may be related to the duration of disease.
