A study of MRI multiparameter assessment of the degree of liver fibrosis in chronic hepatitis B
10.3969/j.issn.1002-1671.2024.11.012
- VernacularTitle:MRI多参数评估慢性乙型肝炎肝纤维化程度的研究
- Author:
Qian LI
1
;
Yukun LI
;
Jun MAO
Author Information
1. 广东医科大学,广东 湛江 524000
- Keywords:
liver fibrosis;
magnetic resonance imaging;
hepatitis B
- From:
Journal of Practical Radiology
2024;40(11):1806-1809,1851
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of MRI T2WI,diffusion weighted imaging(DWI),in-phase and opposed-phase,R2*,and their combined application in assessing the degree of liver fibrosis in chronic hepatitis B.Methods A total of 113 patients patho-logically diagnosed with liver fibrosis in chronic hepatitis B(F1-4 stages)were retrospectively selected,and divided into follow-up group(F1 stage,n=56)and treatment group(F2-4 stages,n=57).The SII value(the ratio of liver to muscle T2WI signal),SIA value[the ratio of liver to spleen apparent diffusion coefficient(ADC)value],SIIP value(the ratio of liver to subcutaneous fat in-phase signal),SIOP value(the ratio of liver to subcutaneous fat opposed-phase signal),and SIR value(the ratio of liver to muscle R2*value)were measured separately for both groups,and their individual and combined diagnostic efficacy in determining the degree of liver fibrosis was compared,and receiver operating characteristic(ROC)curves were plotted.Results Significant differences were observed between the two groups in SII,SIA,and SIR values(P≤0.01,with Z values of 3.833,2.598,and 2.571,respectively),but no sta-tistical difference was found in SIIP and SIOP values between the two groups(P＞0.05).However,statistical significance was found in SIIP values between the two groups among 3.0T MR examination(P=0.009,Z=2.597).The cutoff values for SII,SIA,SIR,SIIP values(3.0T MR),and combined diagnosis of liver fibrosis(F≥2 stage)were 0.70,1.24,1.57,0.61,and 0.37,respectively.The sensitivity was 87.3％,67.9％,41.9％,78.8％,92.6％;and the specificity was 51.9％,56.9％,90.0％,58.3％,82.8％;The area under the curve(AUC)were 0.715,0.646,0.698,0.680,0.871,and the combined diagnosis AUC was higher than the AUC of individual values.Conclusion MRI T2WI,DWI,R2*,and high-field strength in-phase can effectively evaluate the degree of liver fibrosis in chronic hepatitis B,providing a basis for clinical follow-up observation or treatment decisions,with the combined di-agnostic value of multi-sequence parameters being higher.
