Differential value of arterial spin labeling combined with MR spectroscopy for postoperative recurrence and pseudoprogression in patients with high-grade glioma
10.3969/j.issn.1002-1671.2024.10.002
- VernacularTitle:动脉自旋标记联合MR波谱对高级别脑胶质瘤患者术后复发与假性进展的鉴别价值
- Author:
Jingbo HAN
1
;
Miao HE
;
Xinwen WANG
Author Information
1. 山西医科大学,山西 太原 030001;长治医学院附属和济医院影像科,山西 长治 046000
- Keywords:
arterial spin labeling;
magnetic resonance spectroscopy;
high-grade glioma
- From:
Journal of Practical Radiology
2024;40(10):1582-1586
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differential value of arterial spin labeling(ASL)combined with magnetic resonance spectroscopy(MRS)for postoperative recurrence and pseudoprogression in patients with high-grade glioma.Methods A total of 102 patients with high-grade glioma and new or expanded enhancement lesions after radiotherapy were enrolled.According to the results of pathological examination,they were divided into recurrence group(63 cases)and pseudoprogression group(39 cases).The local metabolites of lesions and their ratios,and local blood flow of lesions were compared between the two groups.The differential value of ASL and MRS for postoperative recurrence and pseudoprogression in patients with high-grade glioma was analyzed.Results Choline(Cho)/creatine(Cr)value,Cho/N-acetylaspartate(NAA)value and relative cerebral blood flow(rCBF)of lesion area in the recurrence group were significantly higher than those in the pseudoprogression group(P＜0.05).Compared with actual prognosis,Kappa values of MRS,ASL and ASL+MRS were 0.344,0.448 and 0.712,respectively(P＜0.05).The sensitivity,specificity and accuracy of MRS,ASL and ASL+MRS(parallel mode)were(66.67％,69.23％,67.65％),(76.19％,69.23％,73.53％)and(88.89％,69.23％,81.37％),respectively.The area under the curve(AUC)of receiver operating characteristic(ROC)curve of Cho/Cr value,Cho/NAA value,rCBF of lesion area and combined detection were 0.657,0.844,0.831 and 0.922,respectively.The AUC of combined detection was significantly higher than that of single index(Z=5.028,2.063,2.242,P＜0.05).Conclusion Compared with single detection,the differential ability of ASL combined with MRS is higher for postoperative recurrence and pseudoprogression in patients with high-grade glioma.
